Yes, until there are two entries for F1; one that is enabled during levels 59 and less that won't avoid enochian, and one for level 60 which will avoid enochian, I would recommend using the two profiles as you mentioned in your post, in that way. It can all be merged into one and probably will be soon.
To be clear the difference in rotation should be that you will not cast fire I and possibly fire III while enochian is up. You will cast fire III to get astral fire stacks then proceed to cast fire IV until swiftcast criteria are met, then it empties MP, uses blizzard III, then IV to refresh enochian leaving you with about full MP then nuking them down with fire III then fire IV's. With the profile before that it would waste MP and lose DPS because it would use fire 1 and fire 3 too much while enochian was up.
To be clear the difference in rotation should be that you will not cast fire I and possibly fire III while enochian is up. You will cast fire III to get astral fire stacks then proceed to cast fire IV until swiftcast criteria are met, then it empties MP, uses blizzard III, then IV to refresh enochian leaving you with about full MP then nuking them down with fire III then fire IV's. With the profile before that it would waste MP and lose DPS because it would use fire 1 and fire 3 too much while enochian was up.